中国科学院上海生命科学研究院生物化学与细胞生物学研究所

个人简介

        卒业于理工中学一个地区的动植物。,1988,中等学校如愿以偿了硕士度数,并在那里教。。1990残冬腊月到美国,以工会培育方法先后在加州中学圣地亚哥分校和德州中学圣安东尼奥安康科学心脏达到博士论文,远在1994残冬腊月,奇纳,奇纳科学院上海细胞研究生1995博士。老庚,他译成上海黎族的博士后用水砣测深。。1997,它被聘为研究空军大队的负责人。,副研究员,1999年度展开研究员,博士生任大学导师,老庚改换中科院上海生命科学研究院生化与细胞所。

        2001年度公务的优良青年基金赞助,2005年当选中科院“百人使突出”人才。的改革研究群体的公务的根底学科带头人、科学技术部专攻研究使突出首座科学家。头脑助剂、副主任、学术委任头脑、度数委任主席、奇纳科学院分子细胞生物医用生物头脑、奇纳细胞生物学会副会长。在职者防波堤 Biol 细胞与细胞生物记下副总剪辑、Cell 研究剪辑委任、Faculty of 1000的教练机、奇纳细胞生物学会监控。

       作为细胞内的(公共)相通作者、Nat Cell Biol、Dev Cell、J Cell 记下和支持物记下颁发多篇写论文。上海芍药学科奖、上海学科奖头等奖、上海用水砣测深人才、生命科学改革的第六谭佳振奖、奇纳细胞生物研究生- CST突起的获得奖、公务的优良科技任务者,并屡次如愿以偿中科院“优良教师”、优良研究生任大学导师等敬意。

研究用法说明

细胞周期与有关运动的

研究任务

       细胞周期和细胞有关运动的是生命最根本的典礼。。细胞周期的有意是达到g的甚至辞别。,意识到细胞的增生。而细胞分裂、移动、纤毛有关运动的、细胞使水平横轴回转,如细胞内使水平横轴回转,是很重要的。、复杂、动感圆满,显示出激烈的引力。。人们运用分子生物。、细胞生物和开发生物的多种技术和诡计,和细胞、斑马鱼、鼠标细胞有关运动的建筑风格根底及支持物零碎的深化研究、的分子调控机制,干细胞的把持、辨病相干。它关涉细胞骨架。、分子原动者、心脏粒、细胞的建筑风格和身分,如着丝粒和纤毛,与有重要性使水平横轴回转、打旗语变频、孟德尔基因表达、蛋白质装饰与相互作用的课程。这些使富裕的研究物质充溢了挑动和富有。,期望持有奉献生命科学研究的先生都能找到。。


这样地研究空军大队曾经编队了严厉而绝对的的任务。,在生活中得到享受的勾结和轻快地跳起的氛围,以充溢活力和挑动性的生物来承受生物科学的奉献。、对科学重要技术成就的巴望、对自然美的寻找。

典型性论文

  1. Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, Zhu X*, Zeng YA* (2016). Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor 细胞. PLoS Genet. 12(5): e1006055.
  2. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein 人事变卦率. J Cell Biol. 211(1):7-18.
  3. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y* (2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell. 163(1):108-22.
  4. Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell 谋杀. J Cell Biol. 209(2), 235-46.
  5. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of 建筑风格 repeat-containing proteins critical for cilia formation and 功用。 PLoS ONE. 10(4):e0124378.
  6. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y* (2014). A 小管中间场所 zinc finger protein, 憋气的, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore 对准. Dev Cell. 28(3):268-281.
  7. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 15(12):1434-44.
  8. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X* (2013). The m subunit of murine translation initiation factor 研究 maintains the integrity of the 研究 complex and is required for embryonic development, homeostasis, and organ size 把持。 J Biol Chem. 288(42):30087-93.
  9. Zhou Y, Li S, Huang Q, Xie L, Zhu X* (2013). Nanog suppresses cell migration by 下调 thymosin beta 4 and Rnd3. J Mol Cell Biol. 5(4):239-49.
  10. Yan X and Zhu X* (2013). Branched F-actin as a negative regulator of cilia 编队。 Exp Cell Res. 319(2):147-151
  11. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X* and Zhu X* (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin 动力学。 Nat Cell Biol. 14:697-706.
  12. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, and Zhu X* (2012). Misfolded G beta is recruited to cytoplasmic dynein by Nudel for efficient 清洁. Cell Res. 22: 1140-1154
  13. Wu S, Ma L, Wu Y, Zeng R, and Zhu X* (2012). Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct 的相互作用。 Cell Res. 22:1270-1284
  14. Zhao H, Zhu L, Jin Y, Ji H, Yan X* and Zhu X* (2012). miR-375 is highly expressed and possibly 改观致敏 by ASCL1 in small cell lung cancer 细胞. Acta 生物化学成份与生物 Biophys Sin. 44(2):177-82.
  15. Du J, Li Y, Zhu X* (2010). Involvement of CENP-F in histone 甲基化作用。 Acta 生物化学成份与生物 Biophys Sin. 42(3):173-6.
  16. Du J, Zhang Y, Liu Y, Li Y, and Zhu X* (2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA依赖性 protein 致活酶。 Acta 生物化学成份与生物 Biophys Sin. 42: 839–846.
  17. Yan X, Shen Y, Zhu X* (2010). Live Show of Rho GTPases in Cell 移动. J Mol Cell Biol. 2: 68–69.
  18. Zhu X* (2010). Seeing the Yin and Yang in Cell 生物。 Mol Biol Cell. 21: 3827–3828.
  19. Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposing effects of Ndel1 and α1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1. J Cell Sci. 122, 2820-2827.
  20. Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated 使水平横轴回转。 Traffic. 10:1337-1349.
  21. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin。 PLoS Biol. 7(5): e1000116.
  22. Ma L, Tsai 我, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y* (2009). Requirement for Nudel and dynein for assembly of the lamin B spindle 矩阵. Nat Cell Biol. 11: 247-256.
  23. Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating 细胞. Dev Cell. 14, 342-353.
  24. Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous 小管。 Exp Cell Res. 314, 213-226.
  25. Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome 相异的。 Cell Res. 17, 701-712.
  26. Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M 相。 Mol Biol Cell. 18, 2656-2666.
  27. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent 心脏体 protein 拆卸。 Mol Biol Cell. 17:680-9.
  28. Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell 亡故。 Mol Cell Biol. 25, 4062-74.
  29. Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, 荆 N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription 限定词-4。 J Biol Chem . 280, 13973-7.
  30. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic 动力蛋白。 J Cell Biol. 164, 557-566.
  31. Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward 使水平横轴回转。 Cell Res. 13, 275-283.
  32. Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel 蛋白质. FEBS Lett. 540, 77-80.
  33. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic 主轴. Mol Cell Biol. 23, 1239-50.
  34. Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the 枢纽。 Biochem Biophy Res Commun. 280, 513-517.
  35. Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem J. 345, 749-757.
  36. Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M 相。 Mol Cell Biol. 19, 1016-1024.
  37. Zhu X*, Ding L, and Pei G (1997). Carboxyl terminus of mitosin is sufficient to confer spindle pole 场所。 J Cell Biochem. 66:441-449.

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